Science

Biologics reimagined: Synteins™

Biologics have brought tremendous medical benefit to patients due to their specificity and broad applicability, and yet their therapeutic potential has only been partially realized. Formed by our body’s own building blocks, biologics are often easily recognized by our immune system and disassembled by protein degradation machinery.

Abiologics is combining computational power and chemical flexibility to expand nature’s toolbox and create Synteins™ – a new class of supranatural and programmable medicines. Synteins™ are computationally designed using a broad set of artificial building blocks, far beyond the 20 naturally occurring amino acids. This includes biologics built with D-amino acids, chemically identical mirror images of their standard counterparts. Once designed, Abiologics chemically synthesizes its digitally-optimized Synteins™ to bring life-changing treatments with extraordinary properties to patients across a wide range of diseases.

With the convergence of advancements in generative artificial intelligence, automated polymer synthesis, and chemical functionalization, we are only now able to surpass the limitations of traditional biologics discovery tools, which are equipped to operate solely within the confines of nature. As a result, Abiologics is the first to discover, prototype, and scale-up programmed polymers composed of artificial building blocks.

The Abiologics platform: making the ordinary extraordinary.

The Abiologics platform is a fully integrated digital and automated wet-lab infrastructure that creates supranatural biologics with powerful, desirable pharmacological properties.

Digitally designed

Entering the digital world to design biologics built for purpose

Leveraging artificial intelligence, we can apply the predictable folding rules of natural proteins to create the blueprints for Synteins™ de novo. This enables us to design therapeutics that have novel structures, expanded functions, and advantaged properties like specificity and immune evasion, and do so against virtually any therapeutic target.

Synthetically made

Augmenting nature’s toolkit to develop synthetic biologics

Free from the constraints of biology, we can chemically synthesize these digitally-optimized Synteins™ with pioneering new technologies. As a result, we are creating powerful programmable medicines precisely crafted from artificial components that are inaccessible to nature, yet designed to be compatible with human biology.

Functionally optimized

Operating in stealth to overcome the limitations of today’s therapeutics

With Synteins™, we can now bring the next generation of therapies to life. Natural proteins and biologic drugs are easily neutralized by the body’s defenses. In contrast, Synteins™ remain extraordinarily durable by stealthily evading the body’s natural defenses while maintaining the specificity, broad applicability, and expanded functions that make biologics unique.

Bringing the ideal biologic to life.

Synteins™ have unlimited potential to revolutionize treatment paradigms across a broad range of therapeutic areas. They offer the possibility of less frequent dosing and oral delivery, can reach parts of the human body that were previously impossible to access and treat, and are longer lasting than conventional biologics.

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Today’s scientific advances are enabling us to imagine and create therapeutics crafted from artificial building blocks that are inaccessible to nature, yet compatible with human biology. At Abiologics, we are developing medicines of the future, designed with purpose to transform how diseases are treated.